MIGRADON®
(TABLETS)

COPOSITION:
1tablet contains:
Propyphenazon 250 mg
Paracetamol 150 mg
Caffeine 46 mg
 

CHARACTERISTICS:
MIGRADON®-Tablets have a prompt analgesic, antipyretic effect.
In general they are well tolerated and bring about quick relief of various kinds of pain. Due to the addition of caffeine MIGRADON® is also well suited as an analgesic remedy during daytime.
 

INDICATIONS:
Painful syndromes in general, febrile affections, headaches, toothache, earache, backache, menstrual pain and lumbago.
Administration: With plenty of liquid, whole or dissolved in liquid.
 

CONTRA INDICATIONS:
MIGRADON® must not be taken in case of hypersensitivity to one of its ingredients, severe functional disorders of liver and kidneys, existing impairment of the medulla, genetically caused glucose-6-phosphate dehydrogenase deficiency (a hereditary and very rare metabolic disease), hepatic porphyria (a hereditary enzyme deficiency or acquired metabolic disorder), excessive and or chronic alcohol consumption.
Precautions are to be taken in case of reduced tolerance of analgesics, asthma or chronic inflammation of the respiratory ducts (especially if combined with hay fever and allergic rashes) and hypersensitivity to other analgesics (danger of provoking asthma attacks), as well as ulcers of the gastrointestinal organs or hemorrhaging.
 

PREGNANCY AND LACTATION PERIOD:
MIGRADON®-tablets should not be taken during the first 3 months and during the last 6 weeks of pregnancy. For the rest of the time, use only in case of absolute necessity, keeping to the lowest possible dosage and restricting use to isolated cases.
 

SIDE EFFECTS:
If the recommended dosages are observed, side-effects hardly ever occur. In rare cases reactions of hypersensitivity such as nausea, skin affections (reddening, rashes) have been observed, occasionally accompanied by a rise in temperature ("drug fever") and damage to the mucosa. The caffeine may cause head pressure and disturbed sleep.
In rare cases, a change in the blood count (marked fatigue, paleness, sore throat), asthma, hay fever and swelling of the nasal mucosa may occur. Shock may occur immediately or within an hour of applying propyphenazon.
In case of higher dosages or prolonged use, disorders of the liver and the kidneys cannot be excluded.
Large overdoses of propyphenazon or caffeine may cause a state of daze or unconsciousness, visual disturbances, cramps, overexcitation and disturbances of the heart rhythm.
 

DRUG INTERACTIONS:
MIGRADON®-Tablets may intensify or reduce the effectiveness of different substances and therefore should not be taken together at the same time unless prescribed by a physician.
MIGRADON® intensifies the effects of anti-coagulants, especially when used perpetually, the absorption of paracetamol by metoclopramid, the generation of harmful disintegration products by parallel use of sleeping pills, sedatives, anti-epilepsy remedies and rifampicine.
MIGRADON® reduces the excretory speed of chloramphenicol and the secretion of paracetamol by salicylamide.
Caffeine accelerates the admission of ergotamine.
Simultaneous alcohol consumption increases the risk of liver impairment.
 

SPECIAL WARNINGS FOR SAFE USE:
At the first sign of side-effects and in case of pregnancy the physician has to be consulted before continuing taking MIGRADON®.
In case of impairment of liver and kidney functions, MIGRADON® should not be taken without having previously consulted a physician.
In case of prolonged use or excessive dosages (over 2,0 g of paracetamol/day) damage to liver or kidneys cannot be excluded. Children under the age of 3 years must not be given MIGRADON® unless it is prescribed by a physician. Pronounced hypersensitivity to phenazone derivatives may lead to an impairment of the blood count; if rashes, tiredness, a sore throat or ulcers in the mouth occur a doctor must be consulted. In a few isolated cases severe and even life-threatening allergic shock accompanied by dyspnoea has been observed.
If complaints persist or if the use of MIGRADON® fails to produce the expected result a doctor should be consulted as soon as possible. Simultaneous consumption of alcohol should be avoided!
 

DOSAGE:
If not differently prescribed, please keep strictly to the following dosages:
Adults and children over 12 years: 1 - 2 tablets when required, but not more than a maximum of 5 tablets a day.
Children from 6-12 years: 1/2 -1 tablet when required, but not more than 2 tablets a day.
 

Pack Size:
Package of 2 blister , each blister contains 10 tablets .
 

Storage conditions:
Store at temperatures not above 25°C. In case of doubt seek professional advice.